A Non-Scientist's Intro to the Endocannabinoid System | Easy as A B C

Living in Minnesota, cannabis is recreationally illegal, but I believe on it’s way as the rest of our nation leads by example in legalization. Case in point, states applying cannabis use for opiate addictions are seeing 30%+ in a reduction of overdoses and opiate abuse.

Medically, cannabis brings hundreds of health benefits to both the body and the mind. Studies share it can help quell anxiety, relieve pain, and decrease epileptic symptoms, and these are just a few possible cannabis perks. Cannabis isn’t for everyone, and it’s not a miracle drug. As a avid cannabis coach, the rewards is different for every consumer.


How Cannabis Effects on The Human Body

The reason why cannabis can seem like a magical healer has to do with the endocannabinoid system. This system is present in all mammals. I love the beautiful story of how we’ve existed and relied on plant medicine rapport for ions and ions.

Alright, let’s awaken beauty, here’s how the ECS works, and why it plays a major part in the way we process cannabis and CBD.


Endocannabinoid System Explained

What is the Endocannabinoid System?

You’re probably familiar with the different organ systems of the human body—the skeletal, muscular, and circulatory systems, to name a few—but you might be less aware of the endocannabinoid system, also known as the ECS. Its main function is to ensure homeostasis in the human body, meaning it exists primarily to maintain balance. It was discovered in 1992 when researchers discovered that the body creates its own cannabinoid, called anandamide, which is the Sanskrit word for bliss. The ECS is made up of three different components: endocannabinoids, cannabinoid receptors, and enzymes.

Let’s dive into these biological relationships!

Endocannabinoid Explained Anandaminde

the first discovered naturally-occurring endocannabinoid, which attaches to the same mammalian brain-cell receptors as THC. Its name is derived from the Sanskrit word for “bliss.”

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what makes the endocannabinoid system one of the most important systems in the body because its main function is to maintain balance and homeostasis.

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sit on the surface of cells and transmit information to the inside of the cell, kick-starting the appropriate cellular response.


A Non-Scientist's Intro to the Endocannabinoid System

Endocannabinoids

Cannabinoids are chemical compounds that play a major part in ensuring that the body’s central nervous system functions correctly.

There are three different kinds: endocannabinoids, which are created naturally by our bodies; phytocannabinoids, which mimic the ones in our bodies and are also found in cannabis plants; and synthetic cannabinoids, which are lab-created. Endocannabinoids are known as our “Bliss Molecule,” representing anandamide, and 2-arachidonoylglycerol. These two receptors either bond or send a messaging signal to the ECS, signaling to the cells just what they need to do. (Best boss in town)!

Cannabinoid Receptors

The next aspects of the ECS are the cannabinoid receptors, otherwise known as CB1 and CB2. Many refer to these as the “locks” where the endocannabinoids are the “key.” CB1 receptors are located in the brain, particularly in the parts responsible for mental and physiological functions. CB2 is located throughout the immune system, peripheral nervous system (outside of the brain and spinal cord), and the digestive system. Signaling these receptors allows the body to regulate many important functions, such as digestion, appetite, immunity, inflammation, mood, sleep, fertility, memory, and more.

Enzymes

Once the messages are sent between the endocannabinoids and the receptors, enzymes enter the picture and break these messages down before the party gets out of sync and intuitively transitions the moving parts.

Enter Cannabis!

When we use cannabis and/or CBD, we’re inviting phytocannabinoids into our body, which mimic our natural endocannabinoids to help preserve homeostasis. If for some reason your body is out of whack and cannot bring itself to balance, this is where cannabis proves itself beneficial. It’s know that 20% of society has a ECS Genetic Deficiency, while sub-immune ailments are also now being linked to a sub-par ECS system.

It’s kinda like an adaptogen. Let’s say you’re in pain: cannabinoids will help modulate that pain; if you need help stimulating appetite, cannabinoids can make you hungry. Even beyond the ECS, cannabis effects multiple physiological processes and does what it is needed to get things on the right track.

So that’s the long and short of the KEY PLAYERS between cannabis, CBD and our biology!

Follow along @beautyecology and connect to our Youtube channel to listen up while ya work!

Is Alkaline Water or Hydrogen Water Better?

Hello rays of light!

The issues around water quality are not new, but research that is abrupting the scenes, is. Water quality can detriment a women’s thyroid, to possibly increase fluoride toxicity.

Today’s topic is on the MYTH of pH water, and how H2 Molecular Hydrogen differs.

If you want to tag along via audio, head over to our Youtube channel and LIKE, SUBSCRIBE and SHARE so you can be the ‘early adopter’ you are with all the top shelf science and research delivered straight to your handheld.

So let’s dive in with Dr. Mercola’s teardown on H2 and pH Water!


Alkaline Water or Hydrogen Water — Which One Is Better for You?


STORY AT-A-GLANCE

  • Alkaline water is water that has been separated into alkaline and acid fractions using electrolysis

  • Many promoters and marketers claim alkaline water can correct excess acidity in your tissues, which can then prevent or reverse cancer, arthritis and other degenerative diseases, yet this is not supported by science

  • The higher the pH, the fewer free hydrogen ions (H+) it has; the lower its pH, the more free hydrogen ions (H+) it has

  • Hydrogen ions (H+) are not to be confused with molecular hydrogen (H2 gas); they are completely different from each other. Molecular hydrogen is a gas with very unique and selective antioxidant effects that specifically target damaging free radicals

  • The alkaline ionized water fad was an unfortunate outgrowth of its successful use coupled with a misunderstanding or ignorance of the therapeutic property of the water (e.g., benefits falsely attributed to alkaline pH and not the actual H2 gas)


Understanding pH

The concept of the acidity or alkalinity of your body — or of water — is based on the pH scale. What is pH? It's simply a measure of the concentration of hydrogen ions.10 In fact, the acronym "pH" is short for "potential of hydrogen."

The higher a liquid's pH, the fewer free hydrogen ions (H+) it has; the lower its pH, the more free hydrogen ions (H+) it has. One pH unit reflects a tenfold change in ion concentration, so there are 10 times as many hydrogen ions available at a pH of 7 than at a pH of 8.11

The pH scale goes from 0 to 14, and a pH of 7 is neutral. Anything with a pH below 7 is considered acidic, and anything with a pH above 7 is alkaline (or basic).

But the real reason why alkaline water is a scam is that it has no buffers to maintain its pH. The instant the alkaline water hits your very acidic stomach, the pH is neutralized as there are no buffers. Truly alkaline water would have an alkaline buffer like baking soda (sodium bicarbonate), which is also our body's natural alkaline buffer.

Some have claimed that as the stomach acid neutralizes the alkaline water, the bicarbonate ions are released into the blood and thus it has an alkalizing effect. This would be true if the alkaline water effectively neutralized all the stomach acid (like baking soda would), but alkaline water doesn't neutralize any significant quantity of stomach acid; the stomach acid completely neutralizes the alkaline water. So, there is no "net alkalizing effect."

Natural water on our planet ranges in pH from around 6.5 to 8.5, depending on surrounding soil and vegetation, seasonal variations and weather, and even time of day responses to sunlight. Human activities further influence the pH of our water, from the barrage of toxic industrial pollutants.

Most aquatic animals and plants have adapted to life in water with a very specific pH and will die from even slight changes. For example, Michigan State University found that when the pH of greenhouse media is too high (greater than 6.5), it increases the chances of micronutrient deficiencies in the plants, and too low of a pH (less than 5.3) results in calcium and/or magnesium and/or manganese toxicity.13

Similarly, Ohio State University Extension Service reports that alkaline water affects a plant's ability to obtain nutrients from the soil and can alter the soil's pH over time.14 Your body also requires a relatively stable pH, or else you'll run into problems. This was demonstrated in a Swedish well water study,15 which found both pH extremes to be problematic.

Notably, pH appears to have a major influence on your mitochondria.16 Research has shown normal cells die under extremely alkaline conditions, as a result of altering mitochondrial function.17

So, as noted by Fenton, "alkaline water is a solution to a problem that doesn't need solving." Indeed, it makes sense that you are designed to drink water that occurs naturally, which excludes alkaline water with pH levels of 9.5 and above.

Early Days of Hydrogen Water Production Shed Light on Alkaline Water Myth

Interestingly, aside from Young taking the acid-ash hypothesis and running with it, there's another piece of history that helps explain why the alkaline water myth gained hold. The Molecular Hydrogen Institute explains the history of electrolyzed reduced water or ERW (the most common term used for alkaline water in the scientific literature):18

"Studies on ERW began in the 1930s in Japan, and in 1965 the Japanese Ministry of Health, Labor and Welfare approved ERW as a medical substance with potential to improve gastrointestinal symptoms …

Over the ensuing decades, anecdotal and scientific evidence accumulated substantiating many other benefits of ERW such as: protecting DNA from radical damage, increasing glucose uptake, improving diabetes, preventing premature cell death, offering liver protection, preventing lipid oxidation and others. However, it was uncertain as to how ERW was producing these benefits."

Unfortunately, this is how the misunderstanding about pH came about. However, as noted by the Institute, "It is now well-recognized that the primary agent responsible for the benefits is attributed to the dissolved molecular hydrogen gas." So, in a nutshell, the benefits, when there are any, are actually due to the presence of molecular hydrogen, and has nothing to do with the pH of the water. Dr. Kyu-Jae Lee, a hydrogen gas researcher, says:

We later discovered that the benefits in this model were mediated by H2-induced gastric ghrelin secretion via a ß1 adrenergic receptor-dependent pathway. Although hydrogen's effect in Parkinson's disease has now been confirmed in a human clinical trial, more research is necessary to reveal the molecular mechanisms responsible for the therapeutic benefits of H2.



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What Is Molecular Hydrogen?

Molecular hydrogen (H2) — two hydrogen atoms combined together — is a gas with very unique and selective antioxidant effects that specifically target the most harmful free radicals. It works primarily by improving and optimizing the redox status of the cell when needed.

As a result, you see improvements in superoxide dismutase, catalase and glutathione levels, for example. Not only does hydrogen selectively reduce the most toxic radicals, but it can help prevent an excess (which becomes toxic) of the free radicals from being produced in the first place.

H2 also activates the Nrf2 pathway when needed. Nrf2 is a transcription factor that, when activated, goes into the cell's nucleus and binds to the antioxidant response element in the DNA. It then induces the transcription of further cytoprotective enzymes such as glutathione, superoxide dismutase catalase, glutathione peroxidase, phase II enzymes, heme-1 oxygenase and many others.

A landmark paper  on molecular hydrogen came out in Nature Medicine in 2007, showing 2 percent hydrogen gas was effective at preventing brain damage from ischemia reperfusion and, as an antioxidant, has powerful therapeutic applications.

Hydrogen is the smallest molecule in the universe, and is neutral and nonpolar, which is why its bioavailability is so great. It does not dissociate into its electrons and protons when dissolved in water, so it will not alter the pH of water or your body and has nothing to do with the alkaline water concept.

More than 1,000 peer-reviewed scientific publications have collectively demonstrated that H2 has therapeutic potential in over 170 different human and animal disease models. In fact, hydrogen is shown to benefit virtually every organ of the human body, and the reason for this is because hydrogen actually targets and mitigates the root causes of inflammation and oxidation.


Hydrogen Water Versus Hydrogen Peroxide

Due to the similarity in names, many confuse hydrogen water with hydrogen peroxide (H2O2), and I often get asked if one can get the benefits of molecular hydrogen by drinking hydrogen peroxide in water. This is a dangerous mistake to make, so let me make this point abundantly clear:

Never ingest hydrogen peroxide (3 percent solution).

Hydrogen peroxide (3 percent solution) — the stuff you use to disinfect wounds — is not the same as molecular hydrogen or hydrogen (H2) water. Hydrogen peroxide is for topical use only. You could potentially use it is as a mouth rinse for gingivitis, provided you spit it out and do not swallow, and you can pour a few drops into your ear canal as a remedy to combat cold and flu symptoms. But you should never ingest hydrogen peroxide.

Another common misconception is that adding hydrogen to water will form hydrogen peroxide. As explained by the Molecular Hydrogen Institute:23

"Water has the chemical formula H2O, and hydrogen peroxide has the chemical formula H2O2, which by comparison contains an extra oxygen, not hydrogen. So, it does not, indeed it cannot, form hydrogen peroxide.

The fact is, hydrogen gas does not bond to or react with the water molecules, it just dissolves into the water. It does not create some novel molecule like H4O, which would in fact be chemically impossible to form.

Therefore, hydrogen water and hydrogen peroxide are completely different substances. Furthermore, hydrogen peroxide cannot be used to generate H2 gas or make hydrogen-rich water."

Alkaline Versus Alkalinity

Yet another source of confusion is the issue of alkaline versus alkalinity. These two words are not interchangeable, as from a scientific standpoint as they refer to different things. This too may be part of why people have placed such undue value on alkaline water. As explained by Mark Timmons, CEO of U.S. Water Systems:24

"To alkalize your body means that you give the body the ability to maintain a proper pH, but in order to do that you need water with alkalinity not alkaline water. pH merely measures the degree of acidity or alkalinity, not the capacity to neutralize acid … You also don't alkalize your body based upon pH, but rather on alkalinity.

Alkalinity measures the ability to neutralize acid with buffers which are the sum of bicarbonates. Alkalinity is measured in mg/L (milligrams per liter). Alkaline mineral compounds include … calcium, potassium, magnesium, sodium, manganese [and] iron. So, you need to add alkalinity to your body, but you need to realize that pH has no relation to that alkalinity.

Alkaline Water Is an Unlikely Cancer Preventive

One of the purported health benefits of drinking alkaline water is cancer prevention. However, much of the research really argues against alkalinity when it comes to treating cancer.

According to Robert Gillies, who has studied tumor formation and acidity at the Moffitt Cancer Center,25 tumors make their own acidity by their very nature, and they do this even in an alkaline cellular structure.

Scientists developing anticancer agent prototypes that selectively kill tumor cells by interfering with the regulation of intracellular pH also report that alkaline treatments do not have the desired effect, whereas strongly acidic treatments do!26

Even more interesting is a 2005 study27 by the National Cancer Institute, which revisits the use of vitamin C (ascorbic acid) to treat cancer. They found that, in pharmacologic doses administered intravenously, ascorbic acid successfully killed cancer cells without harming normal cells.

This is yet another example of cancer cells being vulnerable to acidity, as opposed to alkalinity. So, it seems clear that the relationship between alkalinity and cancer has been grossly oversimplified by those jumping to premature conclusions.

Resource: https://articles.mercola.com/sites/articles/archive/2018/11/12/hydrogen-water-vs-alkaline-water.aspx

Is Hydrogen Water [H2] a Drink Never to Forget?

On the ongoing journey of being obsessed with CBD (cannabidiol) and how to assure the most bioavailable formulas for our customers, I discovered the recent up-roar around Molecular hydrogen (H₂).

Follow the fun and H2 education on the GRAM & WATCH the youtube video to this article below!

“What is so novel about HYDROGEN?” Let’s dive in and discover this unique molecular structure.

Simply put, molecular hydrogen acts as a powerful antioxidant.

Consider hydrogen molecules as the nice police force, helping us fight free radicals as we go about our day.


H2 Water

IN DEPTH

Molecular hydrogen (H₂) is the ultimate antioxidant. H₂ is known to eliminate only the most harmful free radicals, and may reduce oxidative stress to better help put our body in balance.

H2 gas is the smallest neutrally charged molecule on earth, giving it free range to instantly cross your cell membranes and the blood-brain barrier, and possibly further allowing it to access DNA and mitochondria within the cell where it has protective action.

The Free Radical Theory of Aging

The Free Radical Theory of Aging holds that the damage free radicals do to our cells, particularly the oxidative stress that free radicals cause, is what causes our bodies to age.

How H₂ Works

Size

Molecular hydrogen is the smallest molecule and the only antioxidant that can access the mitochondria and cell nucleus under certain conditions. Unlike most larger antioxidants, H₂ instantly passes through the cell membrane that may allow immediate benefits.

Non Toxic & 100% Safe

Molecular hydrogens byproduct is water, therefore you cannot overdose nor store in adipose (fatty) tissue.

Homeostasis

H₂ supports the body’s ability to maintain a condition of balance by neutralizing harmful free radicals while also boosting your own internal antioxidant system. This keeps oxidative stress low, supports homeostasis and decreases chance of disharmony.


Can we consume TOO MUCH antioxidant content?

YES, and of certain kinds. There’s been studies that correlate TOO MUCH of a consumption of antioxidants can desensitize the bodies innate defence system. It’s much like the Omega studies that reveal our nation is over-consuming Omega 6 in comparison to omega 3, in which increases inflammation.

Selectivity

H₂ target the harmful free radicals without affecting useful free radicals that sustain inner homeostasis. The concern is that we’re “over doing antioxidants common known as Vitamin A, C, E, folic acid, etc),” which can diminish the good free radicals that the body needs.  H₂ does not.

So as you go on and take your supplements, eat more berries, drink tea, or a glass of wine each night with the idea you intake all the antioxidants you need ….. please STOP and read because there’s a NEW SHERIFF is in town - and now found at Beauty Ecology.


A Free Radical Recap

Free radicals are uncharged or unstable molecules, which make them highly reactive and extremely likely that they’ll pull apart pieces of other molecules to gain stability. In their search for stability, they can damage your body.

H₂ to the Rescue!

So, why am I hooked? When a close Functional Medicine friend of mine threw H2 at me, my eyebrows raised. I was initially skeptical because hydrogen is so abundant, why had we not realized the power of this element before?

With over 1000 clinical studies (for cripes sake), it’s CLEAR this powerful molecule may have potential to contribute to multiple forms of symptoms such as:

*ridding oxidative stress, *better metabolism, *combating brain inflammation, *exercise recovery, *increased energy, *gut healing, *skin clarity, *anti-cancer and more.


THE 15 GAME CHANGING BENEFITS OF MOLECULAR HYDROGEN

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Pretty amazing, right?

Stick around and learn more about how these drops of effervescence may be the single, easiest way to introduce a hydrating “well of youth” to improve our inner health and outer beauty.

Take the Free Radical Aging Theory facts and do something about it today.





Resources:

https://www.ncbi.nlm.nih.gov/pubmed/11510417
https://www.ncbi.nlm.nih.gov/pubmed/23031079
https://www.ncbi.nlm.nih.gov/pubmed/26866650
https://www.ncbi.nlm.nih.gov/pubmed/22520831
https://www.ncbi.nlm.nih.gov/pubmed/24392771
https://www.ncbi.nlm.nih.gov/pubmed/21512236
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865993/
https://www.ncbi.nlm.nih.gov/pubmed/21293445 https://www.nature.com/articles/nm1577
https://www.ncbi.nlm.nih.gov/pubmed/26276082

Is Cannabis (CBD) Safe with Other Medications?

Are you currently thinking about taking CBD, but too nervous to because you're on a medication?   This subject matter comes up a lot, so I thought I'd break it down quickly to bring clarity to the nuances of CBD and drug interactions. 

Cannabidiol (CBD) is one of over 80 phytocannabinoids, or chemical compounds, produced by the cannabis plant.  Starting off, Cannabidiol (CBD) itself has no dangerous interactions with other drugs you may be taking.

The breakdown of CBD and Drug interactions is all in the PATHWAY.

How?   Lets dig in!

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Just How Safe is CBD Oil?

Hemp’s cannabidiol continues to be one of the safest alternative therapies on the market. In a review published in 2017, entitled “An Update on Safety and Side Effects of Cannabidiol,” a Clinical Data author asserted: "In general CBD is the most commonly reported side effects that are relatively rare and mild.   

Comparably to the laundry list of drug symptoms - CBD has a short list of that few experience such as feeling tired or changes in appetite. Everyone has various levels of sensitivities, let alone the importance of making sure you’re buying high quality CBD!

How Does Your Body Metabolize CBD?

It’s important to understand how the human body processes CBD.   Essentially, our body breaks CBD down through metabolization, just like other oral drugs by entering the digestive tract.  Here, they absorbs through the stomach lining into the hepatic portal system. This system is a vital system of veins connecting the stomach to the liver, and also acts as one of the body’s filter systems.

Once CBD enters the liver, it soaks up the P450 enzyme processing capability, inhibiting its ability to break down any other hepatically metabolized drugs. The cytochrome P450-complex enzyme becomes entirely preoccupied with processing CBD, with little to no room to break down other compounds also awaiting metabolization.

While the P450 enzyme interact with CBD, the body virtually stops processing any other pharmaceuticals with the same metabolic pathway. Interestingly, it's not the only P450 inhibitor to worry about.

Grapefruit Too?

Yup, something as natural and nourishing as a grapefruit comes with a similar warning about possible drug interaction. Physicians have long advised their patients to steer clear of grapefruit when taking certain medications.

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If you do wish to pursue CBD as a co-therapy to other drugs, consider seeking medical advice and adjust dosages of any medications only on the recommendation of a doctor.

On the FLIP side, there is also a positive benefit to CBD hemp oil interaction with the P450 enzyme. Once we can make it proven through more robust studies, patients may be able to reduce their dose of other medications if CBD substantially increases the expected potency.

What Drugs Could CBD Interact With?

All drugs mainly metabolized by the liver pose a risk for adverse CBD drug interaction. Considering that 60 percent of clinically prescribed medication is metabolized in the liver via the P450 enzyme, it's not feasible to list them all here. Some of the most common types of medications which may trigger CBD hemp oil interactions include:

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  • HIV Antivirals

  • Steroids

  • Benzodiazepines

  • Antihistamines

  • Calcium Channel Blockers

  • Fentanyl

  • Macrolide Antibiotics

 


Cannabidiol (CBD) itself has no dangerous interactions, but it may interact with other drugs you may be taking according to medical journals.   Here's a list of possible drug interactions.

Why Does CYP450 Matter?

In order to determine the appropriate dosages of medications, doctors make calculations using the average amount of time it takes for various drugs and medications to be processed through the cytochrome P450 system.

If only one drug is being processed, and the system is generally healthy, these averages provide accurate dosage information.

However, certain substances have the ability to affect processing times within this system, making drugs metabolize faster or slower than they would on their own.

Similarly, if the cytochrome P450 system is unhealthy due to problems with the liver or other pre-existing conditions, drugs may not metabolize as they should.

Caffeine and CBD

Caffeine is the world’s most famous and commonly consumed psychoactive drug. Who doesn’t ingest even a little from time to time?

CBD oil is rapidly gaining ground on coffee in terms of popularity and so it only makes sense that people would start combining the two.

As it turns out, the two substances go very well together!

Caffeine is molecularly very similar to adenosine, a compound produced in our bodies that activates the A2a receptor. Caffeine binds to the A2a receptors, inhibiting the reuptake of adenosine.

When adenosine binds to the A2a receptor, the result is what is commonly known as the ‘rest and digest’ effect. Consequently, blocking adenosine from binding results in vasodilation, which increases clarity and alertness.

CBD oil is also a partial agonist of the A2a receptor; so the theory goes that by combining caffeine and CBD, adenosine is blocked across the board, resulting in not only more stimulation, but reduced anxiety (due to CBD’s effects on other neurotransmitters systems).

It is worth noting that these effects depend on the serving size of the CBD. High amounts of CBD are more likely to cause drowsiness and sedation.

Additionally, caffeine is metabolized by a CYP450 enzyme, specifically CYP1A2. As CBD inhibits the CYP450 enzyme system, a slowed excretion rate of caffeine will occur. This can mean the effects of the caffeine will be more prolonged and drawn out. The can be both good and bad!

On the bright side, CBD oil and caffeine together will cause the boost from your morning cup of coffee to last all day instead of just a few hours. On the downside, it’s easy to overdo it and end up wide-eyed in bed when you are trying to go to sleep.

Considering this information, again, it is best to be mindful and cautious when mixing caffeine and CBD.

Can CBD Oil Be Addictive?

One of the most common questions we get is: Can I get addicted to CBD oil? The answer depends on what you mean by “addicted.”

When looking at the chemical impacts of CBD oil, the answer is no. Cannabidiol is not physically addictive in the same way opiates, cocaine, alcohol, and other drugs can be. Also, CBD oil does not produce any physical withdrawal symptoms when you stop using it. In fact, CBD oil is currently being researched as a potential tool for minimizing the severe withdrawal from drugs like opiates.

But, having said that, human beings can get addicted to just about anything including exercise, music, sex, and food.

Because CBD oil can alter essential liver enzymes, it is crucial to do your research, talk to your physician, and figure out how to best consume CBD oil for your specific situation.

Information and education will be your most powerful weapons going forward.

How To Use CBD Oil

When taking cannabidiol, it is important to consume only the recommended serving size.  

Raising or lowering this amount may produce the opposite of the desired effect.

Keep in mind that some people may metabolize cannabidiol differently because of anomalies within the cytochrome P45O (CYP450) enzyme system. And depending on when you take your medications, you may find an unintended increase or decrease in CBD concentrations in your blood.

If you suspect that you are not metabolizing CBD oil as expected, ask your doctor to test your cytochrome P450 enzyme system before adjusting your dosage.

Resource:https://cbdoilreview.org/cbd-cannabidiol/cbd-p-450-enzyme/

Let’s review again.  Simply put…

When taking a dose of CBD, your body’s P450 enzymes will be temporarily inactive.   When enzymes are inactive, it becomes much harder for your body to process almost every drug out there.

This means:

Taking lots of CBD may increase the effects of any prescriptions drugs on your body. As they cannot be processed, the drugs will just stay in your body instead of being digested as they should.

The Good & Bad

The good side is that there may be a possibility reduce the amount of powerful prescription medications you take (speak to your physician before beginning or stopping medication). Regardless of what you take, it’s always best to put less artificial drugs into your body.

The bad side is just that you need to be careful. If you are taking CBD make sure to talk to a medical professional, and reduce the amount of prescription drugs you are taking.

So if you’re uber nervous, before adjusting any current prescriptions, or deciding to use CBD in conjunction with other drugs, always speak to a qualified medical professional.

From experience, many of my clients have been able to significantly lower the dosages of drugs they are using for a variety of ailments and symptoms.  This is the entire reason why CBD can benefit many - with the hope of reducing our use of drugs for everything from anxiety, insomnia, pain and headaches.

Making sure you’re purchasing very high quality CBD is a WHOLE OTHER SUBJECT.

Till next time!  Email me with any questions or concerns!  Hello@beautyecology.com

EVOQ CBD CURING CONCENTRATES

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Top 5 Tips How to Avoid a Allergic Reaction to Hair Color

Hey super natural!  

Have you ever wondered if your hair color is safe, void of lurking chemicals?

More like, what woman hasn’t?!

In this short read (or scroll down to the bottom if you’d rather watch), you’ll learn how avoiding just three letters could potentially save your scalp health and your hair.

I’ve been privileged to be a hair color educator and provide hundreds of women with beautiful hair color for over 20 years behind the chair. This means my hands have been deep in a myriad of ingredients that have been nourishing and good - and some not so great (harmful ingredients).   One of these “bad” ingredient is PPD (para-phenylenediamine).

Before natural was cool and organic was chic, I saw the ingredient safety issues around PPD, let alone it was highly allergenic. For this reason, over the last 15 years I’ve sought out the best hair color lines that provide  a PPD Free and Ammonia free for our hundreds of clients at Beauty Ecology.

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Why PPD  a leading concerning ingredient?

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PPD is a powerful chemical sensitizer and I’ve seen it cause strong allergic reactions in everyday healthy women from out of nowhere.  

The top symptoms and reactions from PPD  are itchiness. Headaches, redness and irritation and at worst, PPD can also cause a anaphylactic shock reaction.    

Research Studies Share the Risk
University of Southern California study found that women who had colored their hair once a month for fifteen years or more had a 50% higher risk of bladder cancer.

A 2004 study published in the International Journal of Cancer, hair colorists who’d been working with color for more than fifteen years had a five-fold risk of getting bladder cancer compared to the general population.

PPD’s also been linked to non-Hodgkin’s lymphoma (in the American Journal of Epidemiology in 2008).

Research at the University in Sweden in 2001, suggests PPD might compromise the immune system, setting off rheumatoid arthritis (women who’d colored their hair for 20 years or more had twice the risk of women who had not).

So what are the best ways to avoid a out of the blue” reaction, worse reactions if already experiencing symptoms and overall better hair and inner health?  


Top Five Tip to Avoid PPD Reactions in Hair Color

  1. Wrap it up.   Ask your stylist to remove risk by foiling lowlights to enclose the color and avoiding the scalp contact.

  2. Go blonder.   By using blonde shades and “lifting” the hair, you avoid dark tones which contain significantly higher levels of PPD.

  3. Go longer between coloring and disguise.  Use a powder to disguise regrowth and use a color conditioner that is PPD free.   

  4. Wear hats, avoid chlorinated pools, wash your hair less—all in the service of keeping your color as vibrant and healthy-looking as possible, so you need to re-color less often.

  5. Prep with Benadryl.   Hopefully you won’t fall asleep while applying color at home, but just in case, taking a anti-inflammatory supplement or OTC Benadryl will reduce symptoms. If you feel the slightest twinge of an allergic reaction after coloring, get medical help right away ( swelling, dizziness, difficulty breathing.)

    Last but not least.
    Always Always Seek out PPD-FREE formulas. The best place to start is to find hair color brands that are void of PPD, or at least very very low. Beauty Ecology is a top referal salon for safe, natural and conditioning hair color.

    - PRESS PLAY & SUBSCRIBE -

Contact our team and let us know if you’d like to benefit from PPD free color today! hello@beautyecology.com

Skin Loving Makeup Makeover Event| RSVP Feb 13th

You get 1 CHANCE and 3 SECONDS to make a good impression.

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Love Your Skin Mineral Makeup Makeover

Tell me, when is the last time…

  • you updated your makeup bag colors that suite you best?

  • detoxed your beauty drawers of chemicals, synthetics & bacteria

PERSONALIZED WITH TOP TIPS FROM MAKEUP EXPERTS

  • learn a new look or technique

  • how to avoid a creased or heavy look

  • contouring to pop features

  • get a natural glowing look

  • how to apply for ease and speed

  • match my colors and quick tips for my age

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SAVE THE DATE

When: 
February 13th

Time: 
3pm - 8pm
___
Investment: 
Makeup Focus Session Only $20

**Spend $75 and receive a FREE GIFT with purchase**

With Amy | National Makeup artist

HOW TO BOOK
Please email us at : hello@beautyecology.com 

Request what time between 3pm - 8pm work best for you.  


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WHY LA BELLA DONNA?

Zero Toxins  |  Confidence without Compromise

Not all minerals are created equal. Conventional makeup and mineral lines include fillers such as talc and dyes that pull the moisture OUT of your skin, leaving the skin feeling tight and caky. 

Other mineral lines also contain nano-particles, which leach into the bloodstream - in which you both loose your coverage and put your health at risk.   

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80% of AGING is from UV rays. 
Makeup should be an extension of skin care and provide every day UV protection.  Four ingredients that enhance your skin and health with
an SPF 50 - on the daily.


HOW TO BOOK

Please email us at : hello@beautyecology.com 

Request what time between 3pm - 8pm work best for you. 

 


A Brief on Your Beauty Pro

 
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Meet Amy - Your Makeup Artist

Amy’s worked with the Prestige line as a top leader with Estée Lauder Companies for over 18 with many additional roles such as a lead Account Executive with multiple retailers.

Amy's passion is to help woman learn about the benefits of safe, high performance makeup and for them to feel their best.  "La Bella Donna products offer natural, prestige, affordable and makeup with skincare benefits  perfect for any women of every age.


HOW TO BOOK

Please email us at : hello@beautyecology.com 

Request what time between 3pm - 8pm work best for you. 

How CBD Interacts With Medicines


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In a previous editorial, I address this topic more in depth, but to get the quick and easy explanation, it’s all rolled out here.

Let’s dig in!

Cannabidiol (CBD) itself has no dangerous interactions with other drugs you may be taking.

But there is one exception:
Full Spectrum CBD might indirectly affect other pharmaceuticals by increasing their strength. This is because CBD stops a certain particle in your body from working effectively.
The liver enzyme Cytochrome P450 is essential for your body. It metabolizes almost all the drugs we consumed. It breaks down the substances you put in your body, and turns them into simpler substances that your body actually knows how to use.
Because of how complicated most medicines are, this means Cytochrome P450 alone allows us to break down over 60% of prescribed medicines.


Sounds important right?

Now this is the issue:
If you take a large dose of CBD, your body’s P450 enzymes will be temporarily inactive.
When those enzymes are inactive, it becomes much harder for your body to process almost every drug out there.

This means:

Taking lots of CBD will greatly increase the effects of any prescriptions drugs on your body.
As they cannot be processed, the drugs will just stay in your body instead of being digested as they should.


What does this mean?
This is both good and bad:

  • The good side is that there may be a possibility to reduce the amount of powerful prescription medications you take (speak to your physician before beginning or stopping medication). Regardless of what you take, it’s always best to put less artificial drugs into your body.

  • The bad side is just that you need to be careful. If you are taking CBD make sure to talk to a medical professional and reduce the amount of prescription drugs you are taking.

Again:

Cannabidiol (CBD) itself has no dangerous interactions with other drugs you may be taking according to medical journals. (more information can be found projectcbd.org).

Here's a list of possible drug interactions on https://www.drugs.com/drug-interactions/cannabis.html


How Your Skin’s Endocannabinoid System’s Changing the Game & Your Genes for Good

Inflammation no mo!

How CBD is Changing the Skincare Game & Your Genes for Good

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Whether it's fighting free radicals, treating blemishes,  or reducing inflammation, the power of cannabinoids (CBD) are proving to be a key for treating a variety of skin concerns.

Researcher and buyer beware, there is a lot of confusion and misinformation out there because of all the red tape  and the plethora of unregulated “me too CBD companies.”

In a previous editorial, we explored the body’s endocannabinoid system which is often referred to as ECS. We discovered the key roles your ECS plays in your overall wellness and outlined how CBD engages to bring equilibrium to your brain and body.

Next, we move onto the ECS and your skin!

Skin's Endocannabinoids System

Being in the skin industry for over two decades, the new re-discoveries around our skin’s very own endocannabinoid system and its own receptor ecosystem findings is beyond exciting. It put me into re-formulation mode (watch for our relaunch 2019).

When out of balance, the skin’s endocannabinoid system results in pathological skin conditions such as: acne, accelerated aging, dermatitis, psoriasis and seborrhea to name but a few.

The Gut Connection to our Skin’s Immunity

It is well-documented that the gastrointestinal tract, which, like the skin, is one of the primary physical barriers of the immune system, has abundant cannabinoid receptor sites.

Now, research has shown that the skin also has an endocannabinoid system of its own, which helps to regulate the production of various hormones and proteins, including cytokine causes the skin to spike into inflammation), which is also involved in the immune response.

The skin’s endocannabinoid system also helps to regulate various cellular processes including proliferation, differentiation, and apoptosis or cell death. Thus, imbalance of this system is responsible for the occurrence of chronic skin conditions such as advanced aging, psoriasis and eczema, and developing targeted cannabinoid therapies may help to control the root of optimal skin health.

Many skin conditions are inflammatory in nature and the anti-inflammatory effects of cannabinoids on skin cells have been demonstrated. Both THC and CBD show anti-inflammatory effects.

What’s happening below the surface.  

Skin flare ups are common whether it’s acne, psoriasis or eczema because hormones like cortisol tell the glands in your skin to make oil, suppress your immune system and can cause an inflammatory response in the skin.  

Applying CBD topically is an effective method for introducing cannabinoids to the skin’s ECS for immediate absorption, and faster results.

Topical Application of CBD

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Topical applications of Cannabidiol can penetrate as deep as one inch from the surface.  Imagine what our Evoq Nano infused CBD can influence at 1 billionth of the size! Topicals containing higher amounts of CBD (5 mg per application) can offer relief from physical pain, arthritis and rheumatism.

Communicating the Connection Points

Skin's Endocannabinoids System

Human tissues have at least two types of cannabinoid receptors, CB1 and CB2, each coupled with a protein. CB1 receptors are expressed predominantly at nerve terminals where they mediate inhibition of neurotransmitter release.

CB2 receptors are found mainly on immune cells, one of their roles being to modulate cytokine release.

Endogenous ligands for these receptors, endocannabinoids, also exist, and examples include the molecule anandamide. These discoveries have led to the development of CB1- and CB2-selective agonists and antagonists and of bioassays for characterizing such ligands. So in the future we can have much more targeted cannabinoid therapies.

Human skin cells or keratinocytes are part of the peripheral endocannabinoid system and showed a unique signaling mechanism of CB1 receptors, which may have important implications in epidermal differentiation and skin development.

How About Scalp and Hair Health?


Cannabinoid receptors have been found in even the smallest nerve fibers controlling hair follicles, and keratinocytes have also been shown to bind and metabolize anandamide, the most abundant endocannabinoid.  Plant cannabinoids Δ-9 tetrahydrocannabinol (THC), cannabidiol, cannabinol and cannabigerol (CBG) for their ability to inhibit the proliferation of a hyper-proliferating human keratinocyte cell line and for any involvement of cannabinoid receptors for ultimate hair health.  

In other research, published in The Federation of American Societies for Experimental Biology (FASEB) Journal, it was shown that cannabinoids produce lipids that can regulate skin conditions such as acne vulgaris, seborrhea and dry skin. They suggested further exploration of cannabinoids as “novel therapeutic tools" to treat dry scalp.   

In summary, we have many studies documenting the contributory nature of cannabinoids, their receptors, and the skin’s endocannabinoid system in the metabolism of psoriasis and eczema and other inflammatory diseases, of which aging of the skin is considered one.

In the coming years there is great hope for the use of targeted cannabinoid therapies to better control our overall skin health.    

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Our topical formulations were developed with the well-being of your skin in mind by enhancing your powerful forces of nature with the highest quality of NANO CBD enhanced formulas soon to be offered in 2019!

Stay tuned, and in the meantime, check out our internal tinctures or One Hit Wonder-ment Skin Oil to get you started here!

All the best, to you and to your skin’s best health. - Kassandra


References:

M.Pucci, C. Rapino,A. Di Francesco, E. Dainese, C. D’Addario, and M. Maccarone, “Epigenetic Control of Skin Differentiation Genes by Phytocannabinoids,” British Journal of Pharmacology 170, no.3 (2013): 581.doi:10.1111/bph.12309

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240254/

https://www.naturalproductsinsider.com/beauty/cannabinoids-hemp-beauty-skin-health


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