Is Cannabis (CBD) Safe with Other Medications?

Are you currently thinking about taking CBD, but too nervous to because you're on a medication?   This subject matter comes up a lot, so I thought I'd break it down quickly to bring clarity to the nuances of CBD and drug interactions. 

Cannabidiol (CBD) is one of over 80 phytocannabinoids, or chemical compounds, produced by the cannabis plant.  Starting off, Cannabidiol (CBD) itself has no dangerous interactions with other drugs you may be taking.

The breakdown of CBD and Drug interactions is all in the PATHWAY.

How?   Lets dig in!

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Just How Safe is CBD Oil?

Hemp’s cannabidiol continues to be one of the safest alternative therapies on the market. In a review published in 2017, entitled “An Update on Safety and Side Effects of Cannabidiol,” a Clinical Data author asserted: "In general CBD is the most commonly reported side effects that are relatively rare and mild.   

Comparably to the laundry list of drug symptoms - CBD has a short list of that few experience such as feeling tired or changes in appetite. Everyone has various levels of sensitivities, let alone the importance of making sure you’re buying high quality CBD!

How Does Your Body Metabolize CBD?

It’s important to understand how the human body processes CBD.   Essentially, our body breaks CBD down through metabolization, just like other oral drugs by entering the digestive tract.  Here, they absorbs through the stomach lining into the hepatic portal system. This system is a vital system of veins connecting the stomach to the liver, and also acts as one of the body’s filter systems.

Once CBD enters the liver, it soaks up the P450 enzyme processing capability, inhibiting its ability to break down any other hepatically metabolized drugs. The cytochrome P450-complex enzyme becomes entirely preoccupied with processing CBD, with little to no room to break down other compounds also awaiting metabolization.

While the P450 enzyme interact with CBD, the body virtually stops processing any other pharmaceuticals with the same metabolic pathway. Interestingly, it's not the only P450 inhibitor to worry about.

Grapefruit Too?

Yup, something as natural and nourishing as a grapefruit comes with a similar warning about possible drug interaction. Physicians have long advised their patients to steer clear of grapefruit when taking certain medications.

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If you do wish to pursue CBD as a co-therapy to other drugs, consider seeking medical advice and adjust dosages of any medications only on the recommendation of a doctor.

On the FLIP side, there is also a positive benefit to CBD hemp oil interaction with the P450 enzyme. Once we can make it proven through more robust studies, patients may be able to reduce their dose of other medications if CBD substantially increases the expected potency.

What Drugs Could CBD Interact With?

All drugs mainly metabolized by the liver pose a risk for adverse CBD drug interaction. Considering that 60 percent of clinically prescribed medication is metabolized in the liver via the P450 enzyme, it's not feasible to list them all here. Some of the most common types of medications which may trigger CBD hemp oil interactions include:

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  • HIV Antivirals

  • Steroids

  • Benzodiazepines

  • Antihistamines

  • Calcium Channel Blockers

  • Fentanyl

  • Macrolide Antibiotics

 


Cannabidiol (CBD) itself has no dangerous interactions, but it may interact with other drugs you may be taking according to medical journals.   Here's a list of possible drug interactions.

Let’s review again.  Simply put…

When taking a dose of CBD, your body’s P450 enzymes will be temporarily inactive.   When enzymes are inactive, it becomes much harder for your body to process almost every drug out there.

This means:

Taking lots of CBD will greatly increase the effects of any prescriptions drugs on your body. As they cannot be processed, the drugs will just stay in your body instead of being digested as they should.

The Good & Bad

The good side is that there may be a possibility reduce the amount of powerful prescription medications you take (speak to your physician before beginning or stopping medication). Regardless of what you take, it’s always best to put less artificial drugs into your body.

The bad side is just that you need to be careful. If you are taking CBD make sure to talk to a medical professional, and reduce the amount of prescription drugs you are taking.

So if you’re uber nervous, before adjusting any current prescriptions, or deciding to use CBD in conjunction with other drugs, always speak to a qualified medical professional.

From experience, many of my clients have been able to significantly lower the dosages of drugs they are using for a variety of ailments and symptoms.  This is the entire reason why CBD can benefit many - with the hope of reducing our use of drugs for everything from anxiety, insomnia, pain and headaches.

Making sure you’re purchasing very high quality CBD is a WHOLE OTHER SUBJECT.

Till next time!  Email me with any questions or concerns!  Hello@beautyecology.com

EVOQ CBD CURING CONCENTRATES

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